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Dr. G. Bozet, MD

  • Articles: 174
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Weight gain and risk of NAFLD: the Nurses’ Health Study II cohort

besity has been identified as a major risk factor for the development of Non-alcoholic fatty liver disease (NAFLD). However, the influence of dynamic changes in adiposity over the life course on NAFLD risk remains poorly understood. MN Kim et al. collected data from 110,054 women enrolled in the Nurses’ Health Study II cohort. They documented...
Read MoreWeight gain and risk of NAFLD: the Nurses’ Health Study II cohort

Economic and Clinical Burden of NASH in T2D patients in the U.S.

Nonalcoholic steatohepatitis (NASH), the aggressive form of nonalcoholic fatty liver disease (NAFLD) is strongly associated with type 2 diabetes mellitus. Patients with both T2DM and NASH have increased risk for adverse clinical outcomes, leading to higher risk for mortality and morbidity. Using a Markov model with 1-year cycles...
Read MoreEconomic and Clinical Burden of NASH in T2D patients in the U.S.

MAFLD and risk of CKD

Nonalcoholic fatty liver disease (NAFLD) is part of a systemic disease that affects many other parts of the body. The association between MAFLD (metabolic (dysfunction)-associated fatty liver disease) and extra-hepatic diseases is not known. The aim of the cross-sectional study by DQ Sun et al. was to compare the prevalence of chronic...
Read MoreMAFLD and risk of CKD

NAFLD cirrhosis: a predictive model of liver decompensation

Non-alcoholic fatty liver disease (NAFLD) has become the most frequently encountered chronic liver disease and is an increasingly important cause of liver cirrhosis as well as other adverse events. The authors of this article retrospectively developed and validated a model to predict hepatic decompensation in NAFLD patients with cirrhosis and compared...
Read MoreNAFLD cirrhosis: a predictive model of liver decompensation

Cholecystectomy as a risk factor for non-alcoholic fatty liver disease development

Hepatic steatosis and gallstone disease are highly prevalent in the general population; the shared risk factors are age, ethnicity, obesity, insulin resistance, metabolic syndrome, atherosclerosis, risk of cardiovascular disease, and mortality. The presence of insulin resistance is the critical element in this association because it represents...
Read MoreCholecystectomy as a risk factor for non-alcoholic fatty liver disease development

Volatomic analysis identifies compounds that can stratify non-alcoholic fatty liver disease

Metabolic dysfunction in liver disease is reflected in the biocomposition of exhaled breath. Analysis of volatile organic compounds (VOCs) in exhaled breath, ‘volatomics’, provides opportunities for non-invasive biomarker discovery and novel mechanistic insights into a variety of diseases. The purpose of this pilot study by R. Sinha et al...
Read MoreVolatomic analysis identifies compounds that can stratify non-alcoholic fatty liver disease

Resection of NAFLD-Associated HCC: Patient selection and reported outcomes

Patients with hepatocellular carcinoma (HCC)-NAFLD are usually older, with more morbidities (especially cardiovascular diseases and metabolic disorders) and have advanced disease at the diagnosis due to the absence of surveillance. Patients with HCC-NAFLD unlikely underwent curative treatments...
Read MoreResection of NAFLD-Associated HCC: Patient selection and reported outcomes