Patients with hepatocellular carcinoma (HCC)-NAFLD are usually older, with more morbidities (especially cardiovascular diseases and metabolic disorders) and have advanced disease at the diagnosis due to the absence of surveillance.
Patients with HCC-NAFLD unlikely underwent curative treatments, and have been reported to have lower overall survival (OS) compared to individuals with HCC related to other aetiologies. However, this difference is not confirmed by data of patient subgroups who received curative treatment.
In their review, C. Campani et al. (Department of Experimental and Clinical Biomedical Sciences “Mario Serio”, University of Florence, Florence, Italy) selected studies published over the past 8 years that analyze characteristics and outcomes of HCC-NAFLD patients who underwent surgery with the aim of identifying features that could predict outcomes and potential selection criteria.