DR. D. BEARD is specialist of Nash Pathology
A Nutritional Approach Increase Vegetable Consumption in NAFLD Patients
The aim of this study was to investigate whether a nutritional intervention motivating increased vegetable consumption would be an effective treatment and diet therapy for patients with non-alcoholic fatty liver disease. During the 6-month intervention .....
Read MoreA Nutritional Approach Increase Vegetable Consumption in NAFLD PatientsNAFLD/NASH: a novel pro-carcinogenic contribution for oncostatin M
Oncostatin M is a pleiotropic cytokine of the interleukin (IL)-6 family that contributes to the progression of chronic liver disease. G. Di Maira et al. (University of Firenze, Italy) aimed to investigate the role of oncostatin M in the development and progression of hepatocellular.....
NAFLD and type 2 diabetes, a review
This review by C. H. Lee et al. (University of Hong Kong, Hong Kong) aims to provide a summary of the latest evidence that support NAFLD as an emerging diabetic complication of increasing importance, and to present the current recommendations...
MAFLD might cause structural damage to brain cells
MAFLD might be considered as a multisystem disease that affects not only the liver but involves wider implications, relating to several organs and systems, the brain included.The present study by S. Nucera et al. (University Magna Graecia of Catanzaro, Italy) ...
Getting to the heart of NAFLD/NASH – the CVD perspective
Nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) are a leading cause of liver diseases worldwide, including hepatocellular carcinoma (HCC). In this review on non-invasive evaluation, Prof. Jérôme Boursier, France, presents a meta analysis focusing on the identification of patients with high risk profile and in need of specific management. Dr. Boursier reviews the two major families of non-invasive tests and discusses the sequential use of tests recommended in the EASL guidelines 2021.
Read MoreGetting to the heart of NAFLD/NASH – the CVD perspectiveLiver transplant recipients: NASH is frequent
To investigate incidence and predictors of NAFLD and NASH by employing noninvasive testing in liver transplant recipients (i.e. controlled attenuation parameter and cytokeratin 18), A. Alhinai et al. (McGill University, Montreal, Canada) prospectively...
NASH limits anti-tumour surveillance in immunotherapy-treated HCC
According to this article by D. Pfister et al. (German Cancer Research Center, Germany), the response to immunotherapy is better in patients with virus-induced HCC than in patients with non-viral HCC (that is, NASH). This might be due to the amount or quality of viral antigens....
Pathogenesis of NASH and dynamic changes in liver macrophages
Macrophage-mediated inflammation is critical in the pathogenesis of NASH. T-cell immunoglobulin domain and mucin domain-4 (TIM-4) is selectively expressed on antigen-presenting cells and modulates various immune responses. However, the role of TIM-4 expressed by Kupffer cells in liver fibrosis remains unclear....
NAFLD risk may be associated to dementia and cognitive decline in older age
The present study aimed to investigate the relationship between NAFLD risk and a dementia diagnosis in a large population-based sample aged >65 years. These findings suggest that “an increased NAFLD risk may be associated to dementia and cognitive decline in older age....
NASH: mobile health intervention for lifestyle modification
Lifestyle modification designed to achieve sustained, modest weight loss remains hopelessly difficult to accomplish for many of patients with NAFLD. Mobile health application use to augment current educational practices will achieve meaningful dietary change and regular physical activity....
NAFLD name change: Requiem or Reveille?
Rather than changing the nomenclature without a strong scientific backing to support such a change, efforts should be directed at understanding NAFLD pathogenesis across diverse populations and ethnicities which could potentially help develop newer therapeutic options.
Read MoreNAFLD name change: Requiem or Reveille?Coffee consumption and NAFLD: A systematic review
The effects of coffee consumption on hepatic outcomes are controversial. This study investigated the associations between coffee consumption and the incidence of NAFLD in the general population and the reduction of liver fibrosis among patients with NAFLD...