Dr. D. Beard

Hepatocellular carcinoma is the fifth and ninth most commonly diagnosed cancer in men and women, respectively, and the fourth leading cause of cancer mortality worldwide. Risk factors for HCC include chronic hepatitis B and hepatitis C, alcohol addiction, metabolic liver disease (particularly non-alcoholic fatty liver disease) and exposure...

Physical inactivity and sedentary lifestyle have contributed to the epidemic of obesity and NAFLD. Moreover, NAFLD and sarcopenia have similar pathophysiological profiles. ZM Younossi et al. assessed the association between physical activity, NAFLD, and sarcopenia, and their contributions to mortality, using data from the National Health and Nutrition...

The results of randomized controlled trials (RCTs) investigating supplemental vitamin D on aminotransferases and cardio-metabolic risk factors in subjects with NAFLD have been inconsistent. A meta-analysis of randomized controlled trials by XF Guo et al. (Institute of Nutrition & Health, Qingdao University...

NAFLD and type 2 diabetes are closely associated phenomena. In contrast to the knowledge about NAFLD and type 2 diabetes, there are limited and inconsistent data on NAFLD prevalence in patients with type 1 diabetes mellitus. Type 1 diabetes and type 2 diabetes show major pathophysiological differences but share certain...

Serum gamma-glutamyl transferase (GGT) is a marker of oxidative stress, associated with increased cardiovascular risk. The impact of smoking on oxidative stress may be aggravated in individuals with NAFLD. ET Oni et al. (Cardiology Division, Heart and Vascular Institute, Einstein Medical Center, Philadelphia, PA, USA) aimed to...

The aim of this retrospective cohort study was to develop a risk nomogram for NAFLD in a Chinese population with T2DM. A questionnaire survey, physical examination and biochemical indicator testing were performed on 874 patients with T2DM...

For many years, double-layer phospholipid membrane vesicles, released by most cells, were not considered to be of biological significance. This stance has dramatically changed with the recognition of extracellular vesicles (EVs) as carriers of biologically active molecules that can traffic to local or distant targets and execute defined biological functions...

Cardiovascular death is an important cause of mortality in end stage liver disease patients undergoing orthotopic liver transplant. Left ventricular diastolic dysfunction is often the early manifestation of cirrhotic cardiomyopathy. In order to understand the risk factors for ventricular diastolic dysfunction in end stage liver disease patients...

The topic of liver biopsy in clinical studies, such as for treatments for NASH, is highly important. Despite limitations, liver biopsy remains the gold standard for the study of liver disease. It is important for the exclusion of alternative diseases and co-morbidities such as autoimmune hepatitis or primary biliary cholangitis...