Commentary
he field of NAFLD and its progressive form, NASH, has, despite the challenges of the COVID-19 pandemic, continued to rapidly evolve in 2020. There have been substantial advances in NAFLD mechanisms, diagnostics, and treatment.
Key developments include the identification of a multiparametric cellular and tissue signature to define disease progression and new insights into the definition of disease progression and advancements in non-invasive diagnostics. The FibroScan-AST (FAST) score non- invasively identifies patients at risk of progressive NASH for clinical trials and potentially in clinical practice.
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Early NASH development: myosteatosis rather than sarcopenia
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Kupffer cells and development of liver fibrosis in NASH