Hepatic lipid droplets and metabolic dysfunction in NAFLD

Commentary

Historically considered simply depots for energy storage, lipid droplets are increasingly recognised to impact a wide range of biological processes. Lipid droplets accumulation (or steatosis) and progression to advanced stages of NAFLD remains to be resolved.

In this review, D. G. Mashek (University of Minnesota, USA) provides a brief overview of the major pathways of lipid accretion and degradation that contribute to steatosis and how they are altered in NAFLD.