NASH Commented Articles 2025 - Page 16 Of 42

NASH Observatory Commented Articles

Non-obese MAFLD is associated with colorectal adenoma

Colorectal adenoma is linked to metabolic dysfunction. S. Fukunaga et al. (Kurume University School of Medicine, Japan) aimed to investigate the impact of MAFLD on the prevalence of colorectal adenoma by comparing it to NAFLD in health check-up examinees in a multicenter retrospective study....

ByDr. G. Bozet, MD
OnMay 4, 2022

NASH Observatory Commented Articles

NASH limits anti-tumour surveillance in immunotherapy-treated HCC

According to this article by D. Pfister et al. (German Cancer Research Center, Germany), the response to immunotherapy is better in patients with virus-induced HCC than in patients with non-viral HCC (that is, NASH). This might be due to the amount or quality of viral antigens....

ByDr. D. Beard
OnMay 4, 2022

NASH Observatory Commented Articles

NASH: bariatric surgery and major adverse liver and cardiovascular outcomes

In this retrospective cohort study of 1158 patients with biopsy-proven fibrotic NASH without cirrhosis, bariatric surgery was significantly associated with a lower risk of major adverse liver outcomes and major adverse cardiovascular events. For the authors, in this study....

ByDr. G. Bozet, MD
OnApril 28, 2022

NASH Observatory Commented Articles

Pathogenesis of NASH and dynamic changes in liver macrophages

Macrophage-mediated inflammation is critical in the pathogenesis of NASH. T-cell immunoglobulin domain and mucin domain-4 (TIM-4) is selectively expressed on antigen-presenting cells and modulates various immune responses. However, the role of TIM-4 expressed by Kupffer cells in liver fibrosis remains unclear....

ByDr. D. Beard
OnApril 28, 2022

NASH Observatory Commented Articles

NAFLD: progressive liver fibrosis

The progression of NASH was initially defined according to a two-hit model involving an initial development of steatosis, followed by a process of lipid peroxidation and inflammation. In contrast, current evidence proposes a "multi-hit" or "multi-parallel hit" model that includes multiple pathways....

ByDr. G. Bozet, MD
OnApril 25, 2022

NASH Observatory Commented Articles

NAFLD risk may be associated to dementia and cognitive decline in older age

The present study aimed to investigate the relationship between NAFLD risk and a dementia diagnosis in a large population-based sample aged >65 years. These findings suggest that “an increased NAFLD risk may be associated to dementia and cognitive decline in older age....

ByDr. D. Beard
OnApril 25, 2022

NASH Observatory Commented Articles

Advancing the global public health agenda for NAFLD

In this global Delphi study, a multidisciplinary group of experts developed consensus statements and recommendations. The resulting consensus statements and recommendations address a broad range of topics that have general relevance for policymakers, health-care practitioners, civil society groups, research institutions....

ByDr. G. Bozet, MD
OnApril 20, 2022

NASH Observatory Commented Articles

NASH: mobile health intervention for lifestyle modification

Lifestyle modification designed to achieve sustained, modest weight loss remains hopelessly difficult to accomplish for many of patients with NAFLD. Mobile health application use to augment current educational practices will achieve meaningful dietary change and regular physical activity

ByDr. D. Beard
OnApril 20, 2022

NASH Observatory Commented Articles

NAFLD name change: Requiem or Reveille?

Rather than changing the nomenclature without a strong scientific backing to support such a change, efforts should be directed at understanding NAFLD pathogenesis across diverse populations and ethnicities which could potentially help develop newer therapeutic options.

ByDr. D. Beard
OnApril 11, 2022

NASH Observatory Commented Articles

Major depressive disorder and NAFLD: the interaction mechanisms

Testing the correlation between MDD and NAFLD, as they mediate and promote each other, gradually forming a vicious circle in patients...

ByDr. G. Bozet, MD
OnApril 11, 2022

NASH Observatory Commented Articles

Diet, physical activity, education level and NAFLD risk

In this cross-sectional analysis of the National Health and Nutrition Examination Surveys, 2017-2018, E. Vilar-Gomez et al. (University School of Medicine, USA) examined the association between diet quality, physical activity, socioeconomic status, and NAFLD risk...

ByDr. G. Bozet, MD
OnApril 5, 2022

NASH Observatory Commented Articles

Coffee consumption and NAFLD: A systematic review

The effects of coffee consumption on hepatic outcomes are controversial. This study investigated the associations between coffee consumption and the incidence of NAFLD in the general population and the reduction of liver fibrosis among patients with NAFLD...

ByDr. D. Beard
OnApril 5, 2022