Dr. D. Beard, Author At PanNASH

NASH Observatory Commented Articles

HbA1c at normal-range levels and NAFLD

Longitudinal observations were performed by C. Chen et al. in a cohort of 2,811 participants with no liver disease at inception. The rate of the conversion to NAFLD was 15.7%, with a steady increase in prevalence...

February 11, 2020

Ppar Articles Commented Articles NASH Observatory

Anti-NASH Drug Development Hitches a Lift on PPAR Agonism.

Well-established drugs that are indicated for the treatment of type 2 diabetes and hyperlipidemia are thought to exert effects that alleviate the pathological features of NASH. One class of these drugs targets peroxisome...

February 4, 2020

NASH Observatory Commented Articles

DNA Hydroxymethylation at the Interface of the Environment and Nonalcoholic Fatty Liver Disease.

NAFLD is a multi-faceted disease with metabolic, genetic, epigenetic, and environmental determinants. An increasing number of studies has also provided evidence for the role of xenobiotics in the genesis of steatosis...

January 29, 2020

NASH Observatory Commented Articles

Evaluation of Dietary Approaches for the Treatment of Non-Alcoholic Fatty Liver Disease: A Systematic Review.

The optimal nutritional approach to treat NAFLD remains unclear. N. Saeed et al. (Department of Internal Medicine, Division of Gastroenterology and Hepatology, University of Michigan Health System, Ann Arbor) conducted a systematic...

January 29, 2020

NASH Observatory Commented Articles

Intrahepatic bacterial metataxonomic signature in non-alcoholic fatty liver disease.

Silvia Sookoian et al. (Institute of Medical Research A Lanari, University of Buenos Aires Faculty of Medicine, Buenos Aires, Argentina) aimed to characterise the liver tissue bacterial metataxonomic signature in two independent...

January 22, 2020

NASH Observatory Commented Articles

Does SEN-V and other non-A-E hepatotropic viruses contribute to the development and progression of non-alcoholic fatty liver disease?

Approximately 10-20% of patients with non-alcoholic fatty liver disease (NAFLD) are at risk of progressing to cirrhosis. The cause of such progression is unclear. SEN-V is a hepatotropic virus that has been associated with more severe...

January 15, 2020

NASH Observatory Commented Articles

Small but mighty: Platelets in NASH and other chronic liver diseases.

Several pleiotropic effects of platelets on liver homeostasis and disease have been identified in recent studies. These effects are distinct from their long-recognized roles in hemostasis and coagulation. Recent evidence...

January 10, 2020

NASH Observatory Commented Articles

Unmasking a Stealth Killer: The Need for Increased Awareness of NASH.

The challenge with NAFLD and its variations is not merely lack of awareness of the disease, but also lack of a full understanding of its diagnosis, etiology, pathophysiology, and treatment throughout the community...

January 7, 2020

NASH Observatory Commented Articles

Pediatric Fatty Liver Disease: reports of NAFLD in patients as young as 2 years of age documented in an article by Dr Ajay Jain, Department of Pediatrics, saint louis university, in the USA.. have been

Pediatric Fatty Liver Disease: reports of NAFLD in patients as young as 2 years of age documented in an article by Dr Ajay Jain, Department of Pediatrics, saint louis university, in the USA..

January 3, 2020

NASH Observatory Commented Articles

Advancing the understanding of NAFLD to hepatocellular carcinoma development: From experimental models to humans.

Nonalcoholic fatty liver disease (NAFLD) has recently been recognized as an important etiology contributing to the increased incidence of hepatocellular carcinoma (HCC). The more aggressive form, nonalcoholic steatohepatitis (NASH)...

December 5, 2019

NASH Observatory Commented Articles

Epidemiology of NAFLD and advanced fibrosis in the French general population: A population-based cohort study in 118, 664 subjects (NASH-CO study).

The aim of this study by L. Serfaty et al. was to assess the prevalence and risk factors of NAFLD and associated liver fibrosis in a French population-based cohort (118, 664 participants) by using using the Fatty Liver Index...

November 25, 2019

NASH Observatory Commented Articles

Analysis of human leukocyte antigen allele polymorphism in patients with non alcoholic fatty liver disease

The human leukocyte antigen (HLA) genes may play a role in the pathogenesis of non-alcoholic fatty liver disease (NAFLD) and its progressive form, non-alcoholic steatohepatitis (NASH). A. Karrar et al. aimed to assess the association...

November 23, 2019