Dr. G. Bozet, MD

Non-alcoholic steatohepatitis (NASH) leads to cirrhosis and is associated with a substantial socioeconomic burden, which, coupled with rising prevalence, is a growing public health challenge. Nevertheless, there has been little research into the socioeconomic burden associated with NASH....

Mitochondrial dysfunction plays a central role in nonalcoholic fatty liver disease (NASH). Zhao et al. report that the mitochondrial circular RNA steatohepatitis-associated circRNA ATP5B regulator (SCAR) account for a considerable fraction of downregulated circRNAs in NASH fibroblasts liver fibroblasts from patients with NASH...

Our current understanding of the natural history of NAFLD is incomplete due to a limited knowledge of patient and clinical factors in addition to fibrosis stages that are associated with progression to advanced liver diseases and death. Thus, the aims of the analysis by Ali Canbay et al. (Department of Internal Medicine, Ruhr-University, Bochum, Germany) were...

In this meta-analysis by A. Lin et al. based on data pooled from all 27 studies, the prevalence of NAFLD among Inflammatory Bowel Disease was 32% (95% CI, 24%-40%) with substantial heterogeneity (I2 = 98%). This prevalence of NAFLD among IBD patients is statistically significantly higher than the prevalence of NAFLD in the general population (25.2%; P < 0.001)...

The goal of K. Cusi et al. (Division of Endocrinology, Diabetes and Metabolism, University of Florida, USA) was to review evidence about the complex association between NAFLD and T2DM, and highlight the potential for disease co-management with the available...

MM Asfari et al. aimed to evaluate the association between polycystic ovarian syndrome and NAFLD using a large national database. Adult female patients (≥18 years) with polycystic ovarian syndrome using the National Inpatient Sample database between 2002 and 2014. The control group included...

Trimethylamine N-oxide (TMAO), choline and betaine serum levels have been associated with metabolic diseases including type 2 diabetes (T2D) and non-alcoholic fatty liver disease (NAFLD). These associations could be mediated by insulin resistance.However, the relationships among these metabolites, insulin resistance and NAFLD have...

In their review, F. Idalsoaga et al. (Departamento de Gastroenterología, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile) aim to summarise current data on the overlapping pathophysiology of NAFLD and alcohol-related fatty liver disease, the available information on alcohol consumption in patients with NAFLD...

NAFLD comprises a spectrum of progressive liver pathologies, ranging from simple steatosis to NASH, fibrosis, and cirrhosis. A liver biopsy is currently required to stratify high‐risk patients. Predicting the degree of liver inflammation and fibrosis using non‐invasive tests remains challenging...

V. Houttu et al. (Department of Experimental Vascular Medicine, University of Amsterdam, Amsterdam, The Netherlands) review the current literature on exercise and the gut microbiome in NAFLD. The human gut microbiome has been found to influence...