Hydrogen sulfide and NAFL

Commentary

Nowadays, H2 S is recognised as the third mammalian gasotransmitter. It plays an important role in inflammation, septic shock, ischaemia reperfusion events, cardiovascular disease, and in liver physiology and chronic liver diseases such as NAFLD.

This narrative review shows that H2 S emerges as a key regulator of liver metabolism and metabolic flexibility. The authors examine the physiological relevance of mitochondrial H2 S oxidation in liver energy homeostasis and its potential implication in chronic liver diseases.