Review: outcome of hepatocellular carcinoma in patients with NAFLD

Commentary

Background: This systematic review and meta-analysis by KM Chin et al. (Singapore General Hospital, Singapore) aimed to compare the outcomes of curative therapy for hepatocellular carcinoma from NAFLD and non-NAFLD aetiologies. They pooled and examined findings for 5579 patients from 9 studies.

In NAFLD-HCC patients undergoing liver resection, they observed improved disease-free survival and improved disease-free survival as compared to non-NAFLD HCC patients.

As stated by the authors, peri- and post-operative morbidity should be mitigated with pre-operative optimisation of comorbidities, and deliberately close post-operative monitoring.