Obese NAFLD children and adolescents: high BMI predicts liver fibrosis

Authors: Moran-Lev H, Cohen S, Webb M, et al.
Published in BMC Pediatr 2021
H. Moran-Lev et al. (Dana Dwek Children’s Hospital, Tel Aviv University, Israel) aimed to investigate the predictors for liver fibrosis and the effects of short-term nutritional intervention on steatosis and fibrosis among obese adolescents with NAFLD...
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NAFLD in the elderly

Authors: Alqahtani SA, Schattenberg JM.
Published in Clin Interv Aging 2021
The diagnosis and management strategies of NAFLD in older adults are sometimes challenging, and certain age-specific factors have to be taken into account. In this review, S. A. Alqahtani (King Faisal Specialist Hospital & Research Center, Saudi Arabia and Johns...
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Diabetic kidney disease, cardiovascular disease and NAFLD

Authors: Perdomo CM, Garcia-Fernandez N, Escalada J.
Published in J Clin Med 2021
NAFLD, cardiovascular disease and chronic kidney disease share a common pathophysiology including insulin resistance, oxidative stress, chronic inflammation, dysbiosis and genetic susceptibilities. The aim of this review by C. M. Perdomo et al...
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Asia, Middle East, North Africa: burden of NAFLD

Authors: Golabi P, Paik JM, AlQahtani S, et al.
Published in J Hepatol 2021
Using Global Burden of Disease data, P. Golabi et al. (Inova Health System, USA) aimed to assess the incidence, mortality, and disability-adjusted life years attributable to NAFLD-related liver complications in Asia, the Middle East and North Africa. As stated by the authors in their conclusion, “NAFLD is poised to contribute to a substantial...
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NASH Epidemic: a call to action

Authors: Kanwal F, Shubrook JH, Younossi Z, et al.
Published in Gastroenterology 2021
NAFLD and NASH are common conditions with a rising burden. As pointed out by F. Kanwal et al. (Baylor College of Medicine, and Michael E. DeBakey Veterans Affairs Medical Center, Houston,USA), “yet there are significant management gaps between clinical guidelines and practice in patients with NAFLD and NASH. Further, there is no single...
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NAFLD unawareness in US adults

Authors: Alqahtani SA, Paik JM, Biswas R, et al.
Published in Mol Metab 2021
MAFLD is closely related to disturbances in systemic energy metabolism, including insulin resistance and atherogenic dyslipidaemia. This review by J. Heeren and L Scheja (University Medical Center Hamburg-Eppendorf, Germany) discusses recent research addressing lipoprotein metabolism in the context of MAFLD...
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Genetic and epigenetic factors determining NAFLD risk

Authors: Jonas W, Schurmann A.
Published in Mol Metab 2021
Predicting the individual risk of NAFLD and determining the probability of disease progression is the basis for further developing prevention and treatment strategies. This requires knowledge of the genetic and epigenetic modifiers of NAFLD for genotype-guided risk stratification...
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Review: MAFLD prevalence in children and adolescents

Authors: Ramírez-Mejía MM, Díaz-Orozco LE, Barranco-Fragoso B, et al.
Published in Med Sci Monit 2021
MAFLD is the most common cause of chronic liver disease in children and adolescents. The risk factors for MAFLD may be prenatal, such as genetic factors, or postnatal, such as obesity and insulin resistance. MAFLD is increasingly recognized in children and adolescents...
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Children with suspected NAFLD: negative for other causes of liver disease

Authors: Yodoshi T, Orkin S, Arce-Clachar AC, et al.
Published in Pediatrics 2021
T. Yodoshi et al. (Cincinnati Children's Hospital Medical Center, USA) aimed to determine the prevalence of alternative causes of liver disease in a multicenter, retrospective cohort of 900 children with overweight and obesity patients aged ≤18 years with overweight and obesity, referred for suspected NAFLD...
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Treatment of 3 major risk factors and fibrosis stage regression

Authors: Yao VJH, Sun M, Rahman AA, et al.
Published in Clin Exp Hepatol 2021
Currently, no established hierarchy exists for the influence of metabolic risk factors on NAFLD progression. In this retrospective cohort study, V. J. H Yao et al. (CUNY School of Medicine/Sophie Davis Biomedical Education Program, New York, USA) investigated and ranked the independent and combined effects of three major risk...
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