Obese NAFLD children and adolescents: high BMI predicts liver fibrosis

Authors: Moran-Lev H, Cohen S, Webb M, et al.
Published in BMC Pediatr 2021
H. Moran-Lev et al. (Dana Dwek Children’s Hospital, Tel Aviv University, Israel) aimed to investigate the predictors for liver fibrosis and the effects of short-term nutritional intervention on steatosis and fibrosis among obese adolescents with NAFLD...
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NAFLD in the elderly

Authors: Alqahtani SA, Schattenberg JM.
Published in Clin Interv Aging 2021
The diagnosis and management strategies of NAFLD in older adults are sometimes challenging, and certain age-specific factors have to be taken into account. In this review, S. A. Alqahtani (King Faisal Specialist Hospital & Research Center, Saudi Arabia and Johns...
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Diabetic kidney disease, cardiovascular disease and NAFLD

Authors: Perdomo CM, Garcia-Fernandez N, Escalada J.
Published in J Clin Med 2021
NAFLD, cardiovascular disease and chronic kidney disease share a common pathophysiology including insulin resistance, oxidative stress, chronic inflammation, dysbiosis and genetic susceptibilities. The aim of this review by C. M. Perdomo et al...
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FIB-4 and NFS: which performance?

Authors: Castellana M, Donghia R, Guerra V, et al.
Published in Am J Gastroenterol 2021
M. Castellana et al. (National Institute of Gastroenterology "Saverio de Bellis," Research Hospital, Italy) conducted a meta-analysis to assess the performance of the FIB-4 and NFS scores, the 2 most common non-invasive tools, for the appropriate selection of subjects with AF for biopsy. A total of 18 studies evaluating 12,604 subjects were included...
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Enhanced liver fibrosis test and recognition of liver fibrosis

Authors: Younossi ZM, Felix S, Jeffers T, et al.
Published in JAMA Netw Open 2021
This retrospective cross-sectional study was conducted among patients recruited from a large, community-based hospital system's outpatient liver clinic from 2001 to 202 in order to determine the performance of the enhanced liver fibrosis (ELF) test as a non-invasive test for assessment of liver fibrosis among patients with NAFLD...
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NAFLD unawareness in US adults

Authors: Alqahtani SA, Paik JM, Biswas R, et al.
Published in Mol Metab 2021
MAFLD is closely related to disturbances in systemic energy metabolism, including insulin resistance and atherogenic dyslipidaemia. This review by J. Heeren and L Scheja (University Medical Center Hamburg-Eppendorf, Germany) discusses recent research addressing lipoprotein metabolism in the context of MAFLD...
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Identifying patients with high-risk NASH: three ultrasound markers

Authors: Sugimoto K, Lee DH, Lee JY, et al.
Published in Radiology 2021
Identifying patients with high-risk-NASH who are candidates for pharmacologic therapy remains a challenge. K. Sugimoto et al. (Tokyo Medical University, Japan) aimed to develop a score to identify patients with a NAFLD activity score of 4 or greater and clinically significant fibrosis...
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Detection of HCC in patients with NAFLD

Authors: Caviglia GP, Armandi A, Rosso C, et al.
Published in Cancers (Basel) 2021
Current surveillance strategy for patients with NAFLD at risk of HCC development is unsatisfactory. G. P. Caviglia et al. (National University Health System, and Yong Loo Lin School of Medicine, National University of Singapore) aimed to investigate the diagnostic accuracy of alpha-fetoprotein (AFP), protein induced by vitamin K...
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Imaging biomarkers of NAFLD, NASH, and fibrosis

Authors: Ajmera V, Loomba R.
Published in Mol Metab 2021
Globally, liver biopsy remains the reference standard for staging NAFLD severity. To diagnose NAFLD and quantify liver fat, MRI proton density fat fraction may be more informative than liver biopsy. In this review, V. Ajmera and R. Loomba (University of California, USA) critically examine the use...
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NAFLD: no liver biopsy in 2/3 patients of a real-world cohort

Authors: Barritt AS, Watkins S, Gitlin N, et al.
Published in Hepatol Commun 2021
Much of the current data on NAFLD are derived from biopsy-based studies that may introduce ascertainment and selection bias. Selection of patients for liver biopsy has implications for clinical practice and the reported epidemiology of NAFLD. The aim of this study was to determine patient factors predictive....
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NAFLD in patients with schizophrenia: early detection should be conducted

Authors: Koreki A, Mori H, Nozaki S, et al.
Published in J Clin Psychopharmacol 2021
ndividuals with schizophrenia have high levels of medical comorbidity and cardiovascular risk factors. Patients with schizophrenia should receive regular monitoring and adequate treatment of cardio-metabolic risk factors. Nevertheless, little is known regarding NAFLD in patients with schizophrenia. A. Koreki et al. analysed the medical...
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Assessment of imaging modalities against liver biopsy

Authors: Troelstra MA, Witjes JJ, van Dijk AM, et al.
Published in J Magn Reson Imaging 2021
Multiparametric MRI is a promising technique to assess hepatic steatosis, inflammation, and fibrosis, potentially enabling non-invasive identification of individuals with active and advanced stages of NAFLD. The aim of the current proof-of-principle study by M. A. Troelstra et al. (Amsterdam University Medical Centres, The ...
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