NAFLD and incident chronic kidney disease

Authors: Kaps L, Labenz C, Galle PR, et al.
Published in United European Gastroenterol J 2020
The association of NAFLD and CKD has been established before. The aim of this large-scale database study was to investigate the role of NAFLD on emerging CKD, the emergence of end-stage renal disease and the identification of additional risk factors which may increase the risk for CKD in Germany...
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NAFLD and acute stroke: factors associated at admission

Authors: Mori T, Yoshioka K, Tanno Y.
Published in Hepatol Int 2021
This retrospective study by T. Mori et al. (Shanghai Jiao Tong University School of Medicine, China) aimed to investigate NAFLD frequency and identify factors associated with NAFLD presence at acute stroke admission.

The authors included stroke patients admitted from 2016 to 2019, within 24 h of onset...

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Serum uric acid level and NAFLD in T2DM patients

Authors: Yu H, Zhao L, Liu L, et al.
Published in Medicine (Baltimore) 2021
This study aimed to investigate the association between serum uric acid level and NAFLD in 583 patients with type 2 diabetes (T2DM) hospitalised in the Department of Hepatology, Yantai Qishan Hospital (China). In this study, multivariate regression analyses demonstrated that after adjusting for confounding factors...
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Sugar and fat increase the risk of advanced liver disease

Authors: Manka P, Syn WK.
Published in Dig Dis Sci 2021
In this editorial, P. Manka Essen University Hospital, Germany) and W. K. Syn (Medical University of South Carolina, USA) comment a study by Benhammou and colleagues, who evaluated the effects of NAFLD risk factors including obesity and diabetes on the long-term outcomes of patients with HCV treated with direct-acting antivirals...
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NAFLD and coronary artery calcium score

Authors: Chen CC, Hsu WC, Wu HM, et al.
Published in Medicina (Kaunas) 2021
This study by C. C. Chen et al. (Department of Family Medicine, Asia University Hospital, Taichung, Taiwan) investigated the association between NAFLD, diagnosed by ultrasonography, and coronary artery calcium score as detected by computed tomography in general populations in 545 patients...
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NASH and exposure to cigarette smoking

Authors: Fouda S, Khan A, Chan SMH, et al.
Published in Clin Sci (Lond) 2021
Consumption of diet rich in fat and cigarette smoking are independent risk factors of NASH and they often occur together in some populations. The present study by S. Fouda et al. (RMIT University, Melbourne, Australia) investigated the mechanisms of high fat diet and cigarette smoking, individually and in combination...
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NAFLD patients and PCI: In-hospital outcomes

Authors: Ali H, Kazmi M, Choi C, et al.
Published in Cureus 2021
This study by H. Ali et al. (Rutgers University New Jersey Medical School, USA) aims to explore outcomes in 429,855 patients who underwent percutaneous coronary intervention with or without placement of drug-eluting stents to determine whether the concurrent diagnosis of NAFLD led to worse in-hospital outcomes...
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NAFLD prevalence in Type 1 diabetes patients

Authors: de Vries M, Westerink J, Kaasjager K, et al.
Published in J Clin Endocrinol Metab 2020
The authors reviewed and screened references in order to estimate NAFLD prevalence in patients with type 1 diabetes, and to explore associated characteristics and outcomes. According to this review, NAFLD prevalence in patients with type 1 diabetes is considerable and is highly dependent on the specific diagnostic modality...
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Fatty liver index and risk of hypertension

Authors: Roh JH, Park JH, Lee H, et al.
Published in Korean Circ J 2020
Little data are showing the association between NAFLD and hypertension in a large-scale cohort study. J. H. Roth et al. (Chungnam National University School of Medicine, Daejeon, Korea) evaluated the ability of the fatty liver index to predict the development of hypertension in healthy individuals, in a large cohort of 334,280 healthy individuals...
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Review: NAFLD, driver of chronic kidney disease

Authors: Byrne CD, Targher G.
Published in J Hepatol 2020
The relationship between NAFLD and chronic kidney disease has attracted much attention recently. NAFLD and chronic kidney disease may share common pathogenic mechanisms, such as insulin resistance, type 2 diabetes mellitus, hyperlipidemia and obesity, and thus may potentially share same therapeutic targets. Growing evidence suggests...
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Treatment of 3 major risk factors and fibrosis stage regression

Authors: Yao VJH, Sun M, Rahman AA, et al.
Published in Clin Exp Hepatol 2021
Currently, no established hierarchy exists for the influence of metabolic risk factors on NAFLD progression. In this retrospective cohort study, V. J. H Yao et al. (CUNY School of Medicine/Sophie Davis Biomedical Education Program, New York, USA) investigated and ranked the independent and combined effects of three major risk...
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NAFLD and cardiovascular diseases

Authors: Kasper P, Martin A, Lang S, et al.
Published in Clin Res Cardiol 2021
In the majority of patients, NAFLD is associated with metabolic comorbidities and is generally considered as the hepatic manifestation of the metabolic syndrome. This review analyses the relationship between NAFLD and CVD, describes the underlying pathophysiological mechanisms...
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