The PanNASH slide kit: educational material for healthcare professionals interested in NASH
calanderBy Prof. Rodencalander7 April 2021

The slide above illustrates the role of PPARα, PPARβ/δ and PPARγ as key regulators of lipid metabolism, inflammation and glucose metabolism. Understanding the role of various peroxisome proliferator-activated receptors and their ligands in clinical practice is very important for the future of NASH management. It illustrates why a “pan” PPAR approach can be beneficial and why more research is needed.

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References

1. Tsochatzis EA, Newsome PN. Non-alcoholic fatty liver disease and the interface between primary and secondary care. Lancet Gastroenterol Hepatol 2018; 3(7): 509-17.

2. 1. Singh S, Allen AM, Wang Z, Prokop LJ, Murad MH, Loomba R. Fibrosis progression in nonalcoholic fatty liver vs nonalcoholic steatohepatitis: a systematic review and meta-analysis of paired-biopsy studies. Clin Gastroenterol Hepatol 2015; 13(4): 643-54.e1-9; quiz e39-40.