MAFLD is closely related to disturbances in systemic energy metabolism, including insulin resistance and atherogenic dyslipidaemia. This review by J. Heeren and L Scheja (University Medical Center
Hamburg-Eppendorf, Germany) discusses recent research addressing lipoprotein metabolism in the context of MAFLD.
For the authors, “liver steatosis and damage have a substantial impact on plasma lipoprotein patterns, dyslipidaemia, and consequently cardiovascular health”. The effect of plasma lipoproteins on MAFLD
is less clear. Research is warranted to understand how uptake of lipoprotein particles into hepatocytes and particularly into liver-resident or -infiltrating immune cells influences MAFLD progression.

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