Pathophysiology

Get an understanding by watching videos on the pathogenesis and natural course of NAFLD and NASH.

AllComorbiditiesDefinitionDiagnosisEpidemiologyManagementNash TreatmentPathophysiologyPPAR Agonists

Clinical Chemistry In NAFLD Part 3 – Biomarkers and Hepatic Fibrosis

Discover the intricate dynamics of Clinical Chemistry in NAFLD with Dr. Guillaume Grzych, a leading expert in medical biology and advanced computational techniques. Dive deep into the pathophysiology of liver fibrosis, explore the potential of biomarkers, and understand diagnostic tools like the AST-to-ALT ratio, FibroTest, APRI, FIB-4, and the ELF Score.
View More ⏩Clinical Chemistry In NAFLD Part 3 – Biomarkers and Hepatic Fibrosis
Clinical Chemistry in NAFLD Part 2 – Biomarkers and Hepatic Steatosis and NASH

Clinical Chemistry in NAFLD Part 2 – Biomarkers, Hepatic Steatosis and NASH

Discover how key biomarkers like Fatty Liver Index and SteatoTest are transforming NAFLD diagnosis and management. Delve into the disease's pathophysiology, the impact of obesity and insulin resistance, and the advancements in specialized liver tests.
View More ⏩Clinical Chemistry in NAFLD Part 2 – Biomarkers, Hepatic Steatosis and NASH
NAFLD Pathophysiologic Role of Intrahepatic Vasculature

NAFLD Pathophysiologic Role of Intrahepatic Vasculature

Dr. Kwanten (Belgium) discusses the pathophysiological role of intrahepatic vasculature in non-alcoholic fatty liver disease (NAFLD). He mentions that portal hypertension is present in patients with NAFLD and can be evident in the early stages which is caused by intrahepatic vascular alterations. Further, he explores the different types of drugs that will help change the course of the disease.
View More ⏩NAFLD Pathophysiologic Role of Intrahepatic Vasculature

The role of fatty liver disease and metabolic comorbidities in the progression on liver diseases

Prof. Luisa Vonghia (Belgium) explores the role of fatty liver disease and metabolic comorbidities in the progression of chronic liver diseases. The key points addressed in this video are that co-existent fatty liver and related metabolic factors, including obesity and diabetes mellitus, exacerbate liver injury in patients with another chronic liver disease(s).
View More ⏩The role of fatty liver disease and metabolic comorbidities in the progression on liver diseases

Interactions between gut microbiota and PPARs in NAFLD

Dr. Nicolas Lanthier (Belgium) reviews the interaction between the gut microbiota and PPARs in NAFLD. He discusses the microbiota and its link to NAFLD and IR, where he explains the key role of the gut microbes in the metabolism of their host and highlights how liver becomes the first organ to be exposed to gut changes.
View More ⏩Interactions between gut microbiota and PPARs in NAFLD
Dr.-Moritz-Peiseler

New insights into the role of inflammation in NAFLD

Dr. Moritz Peiseler (La Charité - Germany), discusses new scientific insights into the role of inflammation in NAFLD / NASH. He presents the spectrum of NAFLD and explains how inflammation can drive all the progressive stages of NAFLD. He also reviews hepatocellular carcinoma (HCC) risks and presents several studies and evolving treatments for NASH.
View More ⏩New insights into the role of inflammation in NAFLD
Prof. Rautou

Liver sinusoidal endothelial cell (LSEC) capillarization in NASH

Prof. Pierre-E.Rautou (France) discusses the effects of Liver Sinusoidal endothelial cell (LSEC) capillarization in patients with NASH. He also reviews the occurrences of LSEC capillarization at the early stages of NASH and its contribution to NASH progression by favoring inflammation and liver fibrosis. For the clinicians, he demonstrates a 24 week study of patients with NASH, exposed placebo and lanifibranor treatments strategies to determine LSEC changes.
View More ⏩Liver sinusoidal endothelial cell (LSEC) capillarization in NASH

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