January 2021

January 19, 2021
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The epidemic of the 21st century in search of the most appropriate name

Several position articles recommended that NAFLD should be renamed to metabolic (dysfunction)-associated fatty liver disease (MAFLD). Read More

January 19, 2021
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Comparing the prevalence of chronic kidney disease (CKD) in patients with either MAFLD or NAFLD

The aim of the cross-sectional study by DQ Sun et al. was to compare the prevalence of chronic kidney disease (CKD) in patients with either MAFLD or NAFLD. Read More

NASH treatment: State of the art in 2020

A dialogue between Prof. Abdelmalek and Prof. Francque about best practices in the treatment of NASH. There are 2 aspects: fibrosis and diagnosis. Diagnosis is a field of investigations. Microvesicles could play a role.

January 19, 2021
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The epidemic of the 21st century in search of the most appropriate name

Despite their high prevalence, nonalcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) remain largely underdiagnosed and undertreated. Some question the name of the disease. To address this issue, some academic societies contribute…

January 19, 2021
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MAFLD and risk of CKD

Nonalcoholic fatty liver disease (NAFLD) is part of a systemic disease that affects many other parts of the body. The association between MAFLD (metabolic (dysfunction)-associated fatty liver disease) and extra-hepatic diseases is not known. The aim of the cross-sectional study by DQ Sun et al. was to compare the prevalence of chronic…

January 14, 2021
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NAFLD cirrhosis: a predictive model of liver decompensation

Non-alcoholic fatty liver disease (NAFLD) has become the most frequently encountered chronic liver disease and is an increasingly important cause of liver cirrhosis as well as other adverse events. The authors of this article retrospectively developed and validated a model to predict hepatic decompensation in NAFLD patients with cirrhosis and compared…

January 14, 2021
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Current management of NASH

NASH is the most common cause of liver disease in Western populations, and its prevalence is increasing rapidly. It is a multifactorial and multisystem disease that can affect multiple organs such as the kidneys, heart and blood vessels, and is closely associated with the components of the metabolic syndrome…

January 14, 2021
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PPARs and immune responses

Peroxisome proliferator-activated receptors (PPARs) are fatty acid-activated transcription factors of nuclear hormone receptor superfamily that regulate energy metabolism. Currently, three PPAR subtypes have been identified: PPARα, PPARγ, and PPARβ/δ. PPARα and PPARδ are highly expressed in oxidative tissues and regulate genes involved in substrate delivery…

January 14, 2021
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NAFLD cirrhosis: a predictive model of liver decompensation

The authors of this article retrospectively developed and validated a model to predict hepatic decompensation in NAFLD patients with cirrhosis and compared this with currently available models. Read More

Current management of NASH

In their mini-review, MD Muthiah et al. discuss the currently available treatment options for NASH, as well as those in late-stage clinical trials. Read More

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