MAFLD and risk of CKD

Nonalcoholic fatty liver disease (NAFLD) is part of a systemic disease that affects many other parts of the body. The association between MAFLD (metabolic (dysfunction)-associated fatty liver disease) and extra-hepatic diseases is not known. The aim of the cross-sectional study by DQ Sun et al. was to compare the prevalence of chronic…
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Current management of NASH

NASH is the most common cause of liver disease in Western populations, and its prevalence is increasing rapidly. It is a multifactorial and multisystem disease that can affect multiple organs such as the kidneys, heart and blood vessels, and is closely associated with the components of the metabolic syndrome…
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PPARs and immune responses

Peroxisome proliferator-activated receptors (PPARs) are fatty acid-activated transcription factors of nuclear hormone receptor superfamily that regulate energy metabolism. Currently, three PPAR subtypes have been identified: PPARα, PPARγ, and PPARβ/δ. PPARα and PPARδ are highly expressed in oxidative tissues and regulate genes involved in substrate delivery…
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